The recent application of ionic solvents, including Ionic Liquids and Deep Eutectic Solvents, to the biomedical context has brought the non-invasive transdermal delivery of pharmaceuticals closer to clinical realization. Choline and geranic acid based ionic liquids (CAGE, Figure 1) have shown excellent biocompatibility and the ability to carry large (ca. 6000 Da) molecules through to the dermis. Using two model drugs of differing hydrophilicities, acarbose and ruxolitinib, and 16 quaternary ammonium carboxylic acid ionic liquids, we examine the dependence of skin penetration on the chemical properties of ILs. We also examine the role of structurally different cations, including imidazolium and pyrrolidinium, on transport. We therefore evidence that systematic investigation of the cation and anion enables the task specific design of ionic solvents for transdermal drug delivery. This talk will elucidate the lessons learnt thus far on the role of stoichiometry and inter-ionic interactions in mediating transport, thus illustrating how delving into the chemistry of this solvent class can provide a straightforward, effective bioengineering design strategy in the use of ionic solvents in transdermal drug delivery applications.

Elucidating design principles of ionic liquids for transdermal drug delivery

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.