Coronary artery disease (CAD) is the number one cause of death nationally. One method of treatment for this disease is through balloon angioplasty along with stent implantation to restore blood flow. In this work, two types of iron-containing metal-organic frameworks (Fe-MOFs) were studied: MIL-53 and MIL-88B. Both materials are composed of iron (III) ligands connected by benzene dicarboxylate linkers by forming three-dimensional structures. MIL-53 is formed through homogeneous nucleation while MIL-88B through heterogeneous nucleation. The different nucleation pathways result in MIL-53 with one-dimensional channels and MIL-88B with a three-dimensional cage. By controlling the crystal structure, we were able to tune drug loading and releasing patterns with ibuprofen as a model drug. We observed that MIL-53 is able to take up larger amounts of ibuprofen than MIL-88B per mg of material. However, the drug elution process is much slower observed for the MIL-88B system compared to its analog material. This indicates that MIL-88B with complex 3D cages is beneficial for regulating drug release in a controlled manner. After identifying the chemical and structural features that influence drug release profiles, we constructed a thin film drug delivery system with MIL-88B. We modified several suitable surface platforms (with specific chemical features) that can be used to construct MIL-88B films. These platforms include COOH-terminated gold and OH-functionalized medical grade stainless-steel substrates. The drug loading/releasing with MIL-88B films were studied in terms of drug encapsulation amount, mass transfer efficiency, and cumulative releasing. The knowledge acquired from these studies will benefit future <i>in vivo </i>studies of Fe-MOF thin film as a drug-eluting stent coating, in addition to the creation of new thin-film materials with potential applications in medical devices. This work aims to enhance the scientific understanding of surface and interface interactions between general three-dimensional materials and assorted therapeutic agents. The results will lead to new insights and guide future drug-eluting materials design.

Using iron-containing metal-organic frameworks as drug-eluting stent coating

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.