We present the influence of salt on the structure and dynamics of zwitterionic unilamellar liposomes and the phospholipid bilayer. We expect that our study will assist current liposomal drug delivery formulations to look at ionic strength in the range of physiological limits in a new light and to close the knowledge gap in the fundamental understanding of biological membrane structure and dynamics in the widely overlooked saline environment. Several structural changes are revealed by techniques such as cryo-transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) with varying NaCl concentration.<br/>We observe a change of the membrane structure and rigidity starting at very small concentrations, leading up to the physiological ionic strength and beyond. We also notice the importance of investigating beyond the established traditional Zilman-Granek analysis with a more advanced model that includes the mobility of fatty acid tails to obtain bending elasticity information.

Physicochemical changes arising in zwitterionic phospholipid liposomes with the presence of salt

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.