Cooperative adsorption describes how insoluble monolayers enhance a soluble solute’s surface activity relative to the solute’s affinity for neat interfaces. Cooperative adsorption’s consequences are far-reaching. Saccharide adsorption to lipid films has been proposed as a mechanism to account for the unusually high organic content reported in sea-spray aerosols, and cooperative adsorption is considered to be one mechanism responsible for concentrating cryoprotectants such as trehalose near cell membranes. Our recent studies of cooperative adsorption have examined the roles played by soluble solute charge and insoluble monolayer composition on cooperative adsorption. Surface specific vibrational sum frequency generation (VSFG) experiments show that monosaccharides such as the anionic glucuronic acid and cationic glucosamine both cooperatively adsorb to DPPC monolayers and induce a higher degree of order in the DPPC acyl chains with increasing saccharide concentration, regardless of charge. Independent surface tension experiments support these findings and show both saccharides to have a condensing effect on DPPC monolayers. Further evidence of cooperative adsorption comes from differential scanning calorimetry (DSC) experiments where glucuronic acid induces a second gel-liquid crystalline transition temperature (~1 degree C higher than the main transition) suggesting that cooperative adsorption leads to partial headgroup dehydration.

Cooperative adsorption: Environmental and biological consequences of organic enrichment by lipid films

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.