Despite several scientific advances, determination of radiation delivered to the patient during cancer therapy remains a challenge due to the inherent limitations of existing dosimeters including fabrication and operation. Here, we describe a colorimetric nanosensor that exhibits unique changes in color as a function of therapeutically relevant radiation dose (3–15 Gy). The nanosensor is formulated using a gold salt and maltose binding protein (MBP) as a templating agent, which upon exposure to ionizing radiation is converted to gold nanoparticles. The formation of gold nanoparticles from colorless precursor salts renders a change in color that can be observed visually. The dose dependent multicolored response was quantified through a simple ultraviolet visible spectro-photometer and the peak shift associated with the different colored dispersions was used as a quantitative indicator of therapeutically relevant radiation doses. This is followed by briefly identifying the location of gold ion mineralsation in protein-gold complex through xray crystallography.

Protein templated gold nanoparticle formation as indicators of ioninzing radiation

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.