Viscosity which increases with increasing protein concentration is a major challenge in developing protein therapeutics, mainly due to protein-protein interactions.  These solutions pose a challenge for both manufacturing and analysis.  However, high protein concentration is desired for Subcutaneous (SC) injection development and for storage of high volume products.  There are several excipients available on the market known to reduce the protein viscosity, but none are suitable for all proteins. Moreover, many of these excipients can have an adverse impact on protein stability and quality.  In this discussion, we will present a novel excipient that is superior to alternatives in viscosity reduction and is also able to stabilize protein by minimizing protein aggregation formation.<br/>

Novel excipient to reduce protein viscosity

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.