Traditional filter technologies and materials are constrained by a tradeoff between selectivity and permeability. In critically important and challenging separations such as downstream virus filtration, this tradeoff translates to sacrificing either patient safety or filtration efficiency. By carefully engineering and exploiting the self-assembly behavior of block copolymers, a new type of virus filter platform has been developed to allow high liquid permeability in conjunction with virus elimination. The self-assembly of block copolymers allows them to be processed into filters with very uniform pore sizes and high pore densities, enabling very high selectivity along with high liquid permeability. In conjunction with a prefilter, these isoporous membranes are part of a powerful new technology platform for biopharmaceutical downstream virus filtration.

Isoporous block copolymer membrane platform for downstream virus filtration of recombinant proteins

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.