Column chromatography is one of the most widely-used techniques to capture and purify monoclonal antibodies (mAbs). It continues to play a major role in the purification of mAbs, from conventional batch processing to multi-column continuous processing.<br/><br/>One of the main reasons for the move to intensified batch processing and continuous chromatography is the need to reduce the cost of goods (COG’s) and improve productivity. Several contributory factors either directly or indirectly affect the COG’s, from resin cost/g purified mAb, facility foot print, to buffer consumption.<br/><br/>In this study, we compare the latest generation protein A resin, Praesto Jetted A50, based on a uniform agarose bead against market leading batch emulsified protein A resins. The results show that significant increases in productivity and reduction of COG’s can be achieved by using purposed designed jetted resins for capture chromatography. Whether used in batch or continuous format.

Batch, continuous or intensified batch processing: That is the question?

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.