Membrane adsorbers have become a popular choice in single-use centric bioprocesses for their ease of operation and high flowrates; however, these membranes are often replaced by a packed bed chromatography operation for late-stage clinical and commercial processes. Packed bed chromatography often provides better fit for late-stage processes, as columns can be packed to scale with increased process volume and can be cycled as production needs rise. This body of work explores the potential for membrane adsorber usage in late-stage processes by pushing the limits of the membrane. High loading, up to 40 kilograms of protein per liter of membrane, challenged the membrane adsorber for HCP clearance and viral clearance. Results were used to evaluate the applicability of this membrane adsorber for a large volume, late-stage bioprocess via an economic analysis including a comparison to packed bed performance.

Application of an anion exchange membrane adsorber in late-stage bioprocesses

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.