The bioprocessing industry is driving towards intensified processes to reduce the cost of goods and/or increase productivity.  From an upstream perspective, there are two areas of focus - intensified seed and intensified production.   Perfused seed is one specific upstream process that plays a role in both areas.  To gain a better understanding of the benefits of incorporating perfused seed trains in mAb production, BioSolve process modeling software was used to perform a holistic cost analysis.  Process models of several different perfused seed train options were generated, as well as a traditional seed train model to compare to.  In this study, scenarios were run evaluating the effect of variables such as production/seed train ratio, number of production bioreactors, titer, and production duration.  Results showed that under certain scenarios, perfused seed train options could deliver lower cost of goods, increase product throughput, or a combination of both.   <br/>

Evaluating perfused seed trains through process modeling and cost analysis

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.