The development of fluorination methods has become very important for the synthesis of many pharmaceuticals, agrochemicals, and 18F-labeled radiotracers for positron emission tomography (PET). Current palladium-catalyzed methods for C(sp3)–H fluorination require the use of directing groups, which limit the scope of the reactions. Here we report a new palladium-catalyzed method for non-directed C(sp3)–H fluorination. Low loadings of a palladium catalyst afford moderate to good yields for C–H fluorination products. This presentation will discuss the optimization, scope, and mechanism of this transformation.

Unusual reactivity of a palladium-catalyzed C(sp3)–H fluorination method

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.