Indole and indolines are commonly found in numerous bioactive molecules and pharmaceuticals. Indole is considered as the fourth prominent heteroaromatic moiety present among the currently marketed drugs. Owing to its biological importance, the synthesis of various functionalized indole derivatives has been an active area of research. Traditionally functionalization on the benzenoid ring system of indole has been achieved through metal-catalyzed coupling reactions using pre-functionalized substrates. In recent years second and third-row transition metal (Rh, Ru, Pd, Ir) catalyzed direct C-H activation and functionalization has been used to achieve derivatives of indole and indolines. The high cost, low availability, and toxicity of noble metals restricts its use in pharmaceutical industries. Therefore there is an urgent need to mimic noble metals using less toxic, more abundant and less expensive first-row transition metals. In this context, cobalt catalysts offer an alternative option to noble metals. In recent years cobalt catalysts have been shown to perform numerous C-H activation reactions, however, in most cases, a strong directing group is required to effect the reaction. Cobalt catalyzed C-H functionalizations mediated through weak coordination is very less explored, therefore in our group we have initiated a program to explore cobalt catalyzed C-H functionalization of indole and indolines using weakly coordinating directing groups. A brief account of our recent results will be presented.

Cobalt(III) catalyzed C-H functionalizations through weak coordination: Synthesis of functionalized indole and indoline derivatives

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.