Amines are an important class of compound, yet their use as substrates in C–H activation has been hindered by the need to convert them into a better directing group. As a result, the development of cheap, easily available, and industrial friendly directing groups is still in demand. Our group has pioneered an approach using carbon dioxide as an inexpensive, catalytic, and transient directing group to allow the arylation of various amine substrates. Recently this methodology has been used to demonstrate a straightforward route to the synthesis of seven-membered lactams via directed C–H activation of a primary amine followed by subsequent cyclization with the newly installed functional group.

Cascade C–H arylation/lactamization of benzylamines enabled by a transient directing group strategy

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.