Thousands of natural products have been discovered that possess potent antimicrobial properties. The vast majority of these natural products did not evolve in human hosts, and thus have not been evolutionarily selected to have desirable therapeutic properties as human drugs. While semisynthetic approaches have provided a repertoire of classes of antibiotics suitable for human use, many other classes have yet to reach their potential. Additionally, clinical resistance has been documented for every marketed class of antibiotics. By developing new chemistry for the assembly of known antibiotic scaffolds, we have been able to overcome several of the limitations that nature left behind, improving known antibiotics and opening the door to new classes.

New antibiotics from old natural products

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.