Today, cancer is the second leading cause of death in the United States. While various drugs have been discovered to treat cancer, many of these also cause damage to healthy cells. Through the design and synthesis of metal-organic frameworks (MOFs) as targeted drug delivery carriers, damage to healthy cells can be minimized during the process of treating cancer. MOFs, a family of porous hybrid materials, have the potential to be selective drug carriers. Previous work has demonstrated that the incorporation of polyethylene glycol (PEG) onto the surfaces of drug carrier MOFs have introduced improved encapsulation, drug release kinetics, and stimuli-responsive delivery. It is aimed to expand research in this field by assessing the success of incorporating PEG onto a larger variety of MOFs for enhanced drug delivery and pH-responsive release. For this assessment and application, MOFs with diverse geometries and pore sizes are selected. The specific MOFs of interest are UiO-66, MOF-808, and NU-1000. This will be accomplished through post-synthetic functionalizing of the MOF surface with PEG, followed by drug loading and release studies.

PEGylation of metal-organic frameworks as targeted cancer drug carriers

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.