<br/>The biopharmaceutical industry is currently focusing on developing higher productivity, more flexible manufacturing processes that incorporate single-use technologies. The use of membranes for high productivity chromatographic purification processes provides compelling advantages, in comparison to tradition resin bead methods, primarily resulting from the rapid, convective protein binding mechanism that underpins membrane operating conditions. This convective binding mechanism can be exploited to achieve very short operating residence times, on the order of seconds, which enables very high productivity purification processes. However, the typical, highly permeable membrane structures that facilitate very short residence time operations exhibit modest binding capacity due to a limitation of binding site density. Advances in membrane science that have focused on resolving this fundamental trade-off have resulted in new chromatographic matrix with resin-like capacity and purification power at much faster process speed (6 seconds residence time). This webinar will focus on the development, characterization, and economic benefits of a novel Protein A affinity membrane, which paves the way for a high productivity, truly single-use chromatography platform for intensified mAb purification.<br/>

Membrane chromatography solutions for single-use, intensified mAb purification

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.