Fabrication of Au doped Ag nanorod with a central twin boundary have been done by a new synthetic protocol. The Bimetallic Au@Ag rod then assembled to form a network type structure with multiple porous crystal sites (low coordinated atomic sites like stepped surface, terrace, grain boundary, twin boundary etc). Dengue serotype-2 related metabolites like L-tryptophan, Blood glucose, vitamin K , vitamin d<sub>3</sub>, vitamin C , Uric Acid have been oxidized electrochemically to get characteristic peak of each analytes in human serum. It was found that Differential Pulse Voltammetry, Chronoamperometry, Electrochemical Impedance Spectroscopy are able to generate a linear calibration plot of each analytes in the physiological concentration level when the Au@Ag network is used as an electrode material to catalyze the reaction. Besides we have also performed aptamer based sensing of real Dengue-2 infected blood both by electrochemically and spectroscopically. The sensing limit of direct virus (serotype2) is well agreed with common lab methods like PCR. The sensitivity was cross checked in presence of other viruses like Dengue-3, Japanese Encephalities etc. Therefore a non-enzymatic protocol has been developed for early detection of Dengue-2 with low cost and high sensitivity,

Crystal engineering to fabricate twin boundary induced highly strained network of Au doped Ag nanorod with excellent catalytic efficiency: Bridging application from catalysis to sensing for early detection of dengue serotype-2 and its related metabolites in human serum

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.