Hollow gold nanomaterials have been widely investigated as photothermal transduction agents (PTAs) in the biomedical field due to the advantages of: 1. high biocompatibility and low toxicity; 2. high photothermal conversion efficiency; 3. tunable optical absorption range in the NIR window I and II. Moreover, the inner cavity of the hollow structures guarantees a high cargo loading efficiency. Thus, gold nanoshell, gold nanocage and gold nanoring have been widely studied. However, anisotropic gold hollow structures, such as Au nanotube, are more favored due to its higher cellular upload efficiency. In my research, anisotropic sub- 100 nm Pt-Au nanotube supported by ultrathin Pt layer was designed and synthesized by a polymer direct template method. The localized surface plasmon resonance (LSPR) band of the nanotube structure can be tuned from 650 nm- 1000 nm. The factors that influence the optical properties were comprehensively investigated. Both experimental results and DFT simulation demonstrated that the LSPR band of nanotubes highly depends on the aspect ratio of the nanotube, the ratio between wall thickness and diameter of the inner cavity as well as the contribution from the layer thickness of the ultra-thin Pt metallic substrate. Importantly, the hybrid Pt-Au coaxial tubular nanostructure exhibited excellent photothermal stability under different laser irradiation conditions compared to pure Au nanorods and can be used as photothermal bactericidal agents. These results point out a potential design based on noble metal materials as recyclable wound dressing materials.

Synthesis of sub-100 nm Pt-Au nanotube with tunable SPR band and investigation of its photothermal bactericidal activity

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.