Biological membranes represent the selective barrier of every cell: they shape organelles, steer vesicles trafficking and modulate interactions with integral and peripheral proteins. Thus, capturing their complexity in terms of lipids composition, concentration and chemical features is crucial to accurately describe protein-membrane interactions. Molecular modelling and multiscale molecular simulations seamless integrated with biophysical/biochemical and structural biology experiments have the potential to characterize the protein-membrane interface at the molecular level. We used this approach to study the functional membrane-binding properties of several protein systems, as those involved in CoQ bio-synthesis at the mitochondrial inner membrane and human acyl protein thioesterases that catalyze S-depalmitoylation regulating protein trafficking across intracellular membranes.<br/>

Integrative modeling at the protein-membrane interface

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.