Polyphosphazenes are a group of chemicals with nitrogen and phosphorus backbones and they have wide applications in different areas. With amino or mixed amino/alkoxy substituents, phosphazenes have shown great biodegradability and bioaccessibility hence are considered as potential candidates for drug delivery. The objective of this project is to synthesize and characterize heterocyclic-substituted polyphosphazenes – Ru(III) complexes. The target products should be able to release functional ruthenium complexes by cleaving P-N or P-O side bonds for biomedical applications. Model studies have been done on oligomers to avoid consuming expensive polymers: cyclochlorophosphazene trimer and tetramer ([PCl2N]3 and [PCl2N]4) have been completely substituted with heterocyclic rings, followed by treatment with different Ru(III) precursors such as (dmso2H)[trans-RuCl4(dmso-S)2]. The structure and the hydrolytic stability of substituted phosphazenes and their metal derivative have been examined by a variety of instrumental analyses including 31P NMR, 1H NMR, IR and UV-vis, mass spectrometry and single-crystal X-ray diffraction. Additionally, DFT calculations have been run on the metal complexes to have a better understanding of the reaction mechanism as well as the interactions between substituted phosphazene and Ru(III).

Synthesis, characterization and DFT calculations of ruthenium(III) heterocyclic-substituted oligophosphazene complexes

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

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