In our continuing effort to develop and study anticancer active platinum compounds we have synthesized a series of platinum compounds coordinated to pyridine thiol (I), tetrahydropyrimidine thiol (II) and Amino acids. Some structural features including biological studies will be discussed during the presentation. Preliminary data suggests that some of these compounds have potential antitumor activity. We have screened the efficacy of the synthesized compounds on ovarian cancer (OC) cell lines. Ovarian cancer accounts for high mortality in American women and is attributed to acquired chemoresistance and unavailability of specific targeted therapy. From our initial screen we have identified two compounds showing bolstered cancer cell killing through induction of apoptosis. In conclusion, these compounds hold promise for better therapeutic outcomes in cancer, including OC.

Biologically important compounds: Synthesis and antitumor studies of nicotinic acid, thionicotinic acid, pryrimidine thiolate and methionine complexes of platinum

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.