Metal organic polyhedra (MOP) were designed and synthesized with paramagnetic iron centers for magnetic resonance imaging (MRI) applications. These MOPs have been characterized in solution using 1H NMR, UV-vis spectroscopy, FT-ICR mass spectrometry, and in the solid state with single crystal x-ray diffraction. Water T1 relaxation properties have been examined with in vitro models showing significant enhancements in the presence of human serum albumen (HSA). In vivo studies of these iron MOPs display contrast enhancements comparable to clinically approved gadolinium based contrast agents (GBCA) while having time dependent localization in vasculature and the intestines of mice.

Paramagnetic molecular organic polyhedra as contrast agents for magnetic resonance imaging

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.