A methodology to achieve copper-catalyzed regioselective boracarboxylation of vinyl arenes has been reported by the Popp group. This transformation uses the cheap, abundant C1 feedstock of carbon dioxide to access highly functionalized α-aryl carboxylic acid derivatives. Expansion of boracarboxylation to vinyl indole, benzofuran, and benzothiophene substrates has been achieved to provide interesting organic moieties. The derivatization of the boron atom through Suzuki cross-coupling has led to a new method to synthesize 2,3-diarylpropionic acids, which find prevalence in pharmaceuticals. While other routes typically rely on the sterics and electronics of the aryl substituents, this new route allows for control of the regioselectivity of the carboxylic acid.

New methodology to controlling regioselectivity utilizing a copper-catalyzed boracarboxylation

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.