Nonylphenol is alkylphenol compound and often detected in the environment. It is widely used as intermediate in industrial processes to produce pharmaceuticals, pesticides, detergents, paints, personal care products, plastics, to name a few, and released into the environment including the water supply.  The 4-branched nonylphenol represents that found in environment best and is selected along with 4-tert-octylphenol as target analytes. The current health reference level (HRL) from Minnesota Department of health for nonylphenol is 20 µg/L. In this study, the minimum reporting limit (MRL) that is far below the HRL was established for branched nonylphenol and 4-tert-octylphenol after a method for identification and quantification of both compounds in drinking water samples was evaluated, using Agilent 1290 Infinity II LC coupled to an Agilent 6470A triple quadrupole LC/MS system with Agilent MassHunter workstation software. The sample preparation consists of loading water sample onto SPE cartridge and eluting with acetone. The challenges including contamination, buffer selection, and solvent effect encountered during the LC conditions optimization are discussed. The method was evaluated and quantified with isotopically labeled internal calibration curve, showing satisfactory results, including identification, selectivity, linearity, MRL, accuracy, and precision.

Quantification of nonylphenol and 4-tert-octylphenol in drinking water using UHPLC-MS/MS

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.