Marine natural product extraction is one of the most promising practices performed in the field of chemical research. In this practice, products are screened in an attempt to elucidate their compound structure. Much is known about the specific structures of the compounds, such as the functional groups present, but little information is available about their biological activity. Prior experiments proved that many marine natural products, most notably the caucanolides, showed inhibitory effects towards breast cancer cells. The conducted research attempted to build off of the experiment, and verify whether other caucanolides could produce similar results. The caucanolide known as Kallosin along with its unidentified byproduct, was administered towards breast cancer cells. The IC<sub>50</sub> value was monitored and plotted on a graph depicting the extent of a biological function against the concentration of the compound. A BrdU Incorporation Assay was utilised as a verification process, to assess whether or not the breast cancer cells continued replicating after being treated with Kallosin and its byproduct. The results were plotted on the graph, while the IC<sub>50 </sub>value was obtained. Inhibition of the cancer cells was reported within the data. The findings provide another means of breast cancer cell inhibition, while also giving a deeper insight into the biological properties of caucanolides.

Effects of caucanolides on breast cancer cells

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

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