Virus filtration remains one of the most variable process steps in downstream mAb or protein purification. It is also a dominant expendable cost for DSP. Existing commercial VF membranes are based fundamentally on an extension of ultrafiltration technology. To achieve acceptable LRV values, this conventional technology leads to sacrifices in capacity due to broad pore size distributions. In contrast, ISOBLOCK self-assembling technology results in filters with periodic, ordered pore structures, enabling high throughput while maintaining high virus retention. Four key membrane properties can influence both capacity and virus LRV: pore size distribution, membrane asymmetry, surface chemistry, and membrane thickness. Data will be presented to show the effects of these properties and ultimately how they fit into the design of a downstream VF process.

Development of isoporous block copolymer membranes for virus filtration: Effects of structural and chemical features on throughput, LRV, and robustness

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.