Process simplification underlying EASY Process has one main goal : bring the monoclonal antibody production process to higher productivity while keeping purification simple and independent from complex technologies. The main objective of such development was to make this new process the most versatile as possible, purifying in the same way, and without heavy modifications, all kind of modalities proposed to DSP development teams (mabs, Fabs, multispecific…). At least for first consequence, the reduction of development duration from weeks to hours. Then to open the possibility to purify in a continuous manner, using disposable technologies, thus increasing the productivity and reducing the batch preparation times. Finally to incorporate this process in a compact and mobile unit concept - plug & play - adapted to all types of facilities. In other words, key drivers leading to design EASY Process is the elimination of chromatographic steps (ie no more columns, resins, expensive ProteinA, buffers, huge chromatographic systems) moving to a very simplified process : -No more preparation of dozen of buffers, columns packing, equilibration, regeneration and sanitization of equipments -No more storage and control of media with disposable technologies -Process cycle time shortened to complete the entire purification in less than 5 hours taking into advantage a novel state-of-the-art disposable technologies (ie membrane adsorbers and filters) . -Continuous processing with small and mobile purification units in order to allow maximum process closure, automatisation to avoid potential contamination and human-based errors Finally, a huge reduction of CoGs associated to monoclonal antibodies purification and a first disposable mobile purification unit created.

EASY Process: ProteinA free, disposable and continuous monoclonal antibodies purification process

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.