Cryogels have been extensively utilized in multiple biomedical and bioengineering approaches due to their high adsorption capacity, macroporosity, high flexibility, and long durability. In particular, composite cryogels hold great potential in terms of easy fabrication, as well as high selectivity, specificity and reusability parameters. In this study, molecularly imprinted magnetic silica microspheres are embedded in poly(2-hydroxyethyl methacrylate) based cryogels to develop a composite carrier for tyrosine purification-crucial chemical in umpteen cellular mechanisms including brain regulation, control of mood, reduction of stress level, production of melanin pigment, and regulation of thyroid functions. Through surface sensitive characterizations, magnetic silica microspheres and composite cryogels were synthesized in a batch system for optimum tyrosine adsorption. The maximum tyrosine adsorption capacity is reported as 62.27 mg/g in pH 8.0 buffer solution at room temperature. The reusability of the composite carrier is tested with serial adsorption-desorption steps using 0.1 M NaCl, presenting that the composite carrier can be used more than 8 times without losing the performance. Competitive binding tests with different amino acids demonstrate high selectivity of the camposite carrier. Mathematical modelling is used to examine experimental data in competitive binding studies.

Preparation of composite carriers for potential application in biomedicine

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.