As the Army moves towards equipping the soldier with more advanced wearable sensing devices for real-time environmental, health, and performance monitoring, there is a significant need for the biological receptors integrated into such devices capable of consistent performance in multifaceted operational environments.  The temperature and biological instability, long development times, and inconsistencies in production of monoclonal antibodies, the gold standard receptors for biological detection, has resulted in the advent of alternative antibody technologies to fill these technological gaps.  Protein Catalyzed Capture (PCC) agent technology is capable of the bottom-up development of highly stable and tailorable receptors through iterative <i>in situ </i>‘click’ chemistry cycles with one-bead-one-compound (OBOC) peptide libraries.  Aside from the inherent thermal stability and binding performance comparable to, and oftentimes exceeding, monoclonal antibodies, the modularity of PCCs allows for easy integration into various detection platforms and assays.  Capable of full receptor development in ~2 weeks, PCCs can fulfill the need for alternative antibodies by addressing critical gaps in adaptability, manufacturability, and stability.  This broadly enabling technology has the capability of benefiting multiple Army entities in a wide range application spaces.

Ruggedized peptide-based receptors for biological sensing in military environments

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.