The economics of a bioprocess are generally driven by the expense of the downstream separation of the bioproduct from dilute aqueous streams. Continuous separation techniques, such as, <i>in situ </i>product recovery (ISPR) are attractive in that they can simultaneously remove and concentrate products from bioreactors, thereby minimizing product inhibition, overall energy footprint, and downstream separation cost by providing a form of process intensification. Although there are multiple benefits of ISPR, there are few reports of its integration with further downstream processes to recover highly pure bioproducts. This seminar will cover recent work in developing a robust ISPR system to recover carboxylic acid products from sterile monocultures, and from non-sterile anaerobic digestors. Results will be presented showing the enhanced effects the system has on microorganism titers, rates, and yields. In one application the system was able to reduce fermenter size by a factor of ~10 compared to a standard fed batch fermentation. Additionally, the system’s application to an anaerobic digestor is found to effectively arrest methanogenesis producing higher value volatile fatty acid products that can be used as platform chemicals in lieu of methane.

<i>In situ</i> product recovery systems increase performance metrics in bioprocesses

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

In situ product recovery systems increase performance metrics in bioprocesses