Natural products have played an integral role in the drug discovery process, providing therapeutic leads as well as chemical probes to unravel complex biological pathways.  We have developed in integrative approach to the discovery of bioactive natural product through combination of chemical, biochemical and bioinformatic driven approaches. This has led to the discovery of a number of sub-type selective toxins against non-small cell, including products ikarugamycin, the bohemamines and discoipyyrole A. Furthermore, we have identified an unusual route to the biosynthetic formation of the discoipyrroles that utilizes a non-enzymatic, multi-component cyclization cascade. We have been able to harness this chemistry with discoipyrroles to generate analogs that have greater potency and PK properties. To follow on the non-enzymatic discovery of discoipyrroles, we have developed tools to increase the understanding of the function of non-enzymatic chemistry in natural products. Utilizing the natural products, dimaritide A and oxazinin A, I will highight the use of isotope-labeling NMR studies to understand the non-enzymartic mechanism of formation and how the mechanisms can be used for improving biological activity of the natural products.<br/>

Chemical and functional characterization of natural products

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.