The wide chemical diversity of natural products from marine invertebrates (sea sponges, ascidians, soft corals, etc), algae and microbes, is often matched by potent biological activity; indeed, several marine derived-drugs have now been approved as therapeutics. The history of natural products are linked to organic chemistry as the “engines of its development ( E. J. Corey), and structure elucidation is still at the heart of natural products discovery. Despite advancements in modern spectroscopy, challenging problems in establishing constitution and stereochemistry still arise. My research group has seized upon those as opportunities for development of inventive tools in marine natural products (MNPs); not only in NMR and CD spectroscopy (our 'nanomole-scale' project to fully characterize minute samples), but also synthetic methodology. Over the years, I have come to view the discovery of new molecules as not so much a matter of compound procurement, but bringing to light chemical information by uncovering the blueprints embodied in the bond constitution and stereochemistry that propels further investigation in multiple disciplines: pharmacology, chemical ecology included, and of course, total synthesis. In this talk, I will illustrate highlights of the past three decades of independent research in MNP chemistry, along with newer results. The objective is to share the extraordinary, rich landscape of structural and biological chemistry that first captured my imagination, and continues to inspire collaboration and exploration at the edge of new scientific frontiers.

Marine natural products: Discovery and invention from the 'wine dark sea'

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.