Tau is an intrinsically disordered peptide that plays an important role in the cell by binding to microtubules. Under pathological conditions, Tau can form fibrillar aggregates, a process that has been linked with Alzheimer’s disease. In addition to forming fibrils, the Tau protein can also phase separate into a protein rich and a protein depleted phase, a process known as liquid-liquid phase separation (LLPS). I will present field theoretic simulations that map out the phase diagram for Tau coacervation. The phase diagram is then used to predict the conditions under which Tau can be driven towards LLPS under <i>live </i>cell coculturing conditions.<br/> <br/>

Fibrillization and liquid-liquid phase separation of the tau peptide

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.