Vinylogous amines, and chloroenals derived therefrom, are very versatile reagents for the regioselective synthesis of unsymmetrical polysubstituted pyrroles and isoquinolones based on extensive research by Gupton.  We report here our attempts at using a flow chemistry platform to accelerate optimization of individual reaction steps as well as for the overall telescoped four-step syntheses of polysubstituted pyrroles. In particular, a Design of Experiment (DOE) for optimizing the final ring closure step will be presented.

Flow chemistry used for optimization (DOE) of four-step synthesis of polysubstituted pyrroles

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.