Collagen is widely used in the fabrication of biomaterials as it is the primary component of the extracellular matrix. For this reason, it has a wide variety of biomedical applications such as tissue engineering scaffolds, drug delivery patches etc. However, a major drawback of collagen-based materials is their susceptibility to mechanical failure during handling, which limits their applicability to biomaterials. Chemical or physical treatment can improve the mechanical properties of collagen however, these processes can create issues of cytotoxicity or denaturation. We report an alternative approach to enhance the stability and mechanical properties of collagen through thermal treatment in fluorous media. Our treatment significantly increases mechanical strength, reduces rate of proteolytic degradation, and provides high cell biocompatibility while preventing denaturation.

Thermal treatment of collagen films in fluorous media for enhancement of mechanical and enzymatic stability

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.