It is necessary to develop new and effective antibacterial agents to reduce the risk of bacterial infection，because of the mounting prevalence of antibiotic abuse and the formation of resistant bacteria. Here we present the photocatalytic bactericidal properties of curcumin (CCM)-loaded metal-organic frameworks (MOFs). The as-synthesized ZIF-8@CCM NPs possess high drug loading capability (14.3%), good chemical stability and fast drug release in bacterial acidic microenvironments. Improve the stability of curcumin in a neutral or alkaline environment and don’t affect the photosensitivity of curcumin. ZIF@CCM showed enhanced antibacterial activity toward Gram-negative E. coli and Gram-positive S. aureus compared with zeolitic imidazolate framework-8 (ZIF-8), curcumin alone and control group without irradiation, due to the cooperative antibacterial effects of the silver nanoparticles and curcumin. Thus, our study provides a new pathway in the rational design of combination strategy for efficiently preventing the ubiquitous bacterial infections.

Nanoscale zeolitic imidazolate frameworks with curcumin loading for blue light response antibacterial

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.