Abstract: Antimicrobial agents with high efficiency and ensured safety have been greatly demanded to meet the public needs of microbial contamination prevention, food safety improvement, and food product shelf life extension. Ag-based nanostructures have been widely studied as antimicrobial agents for their remarkable features of broad-spectrum antimicrobial activity, high surface to volume ratios, facile synthesis methods, and the property of not inducing drug resistance in microorganisms. However, the application of Ag-based nanostructures was limited by the challenges of improving antimicrobial efficacy, reducing application doses, and decreasing toxicities. Moreover, most reported Ag-based nanostructures (e.g. silver nanoparticles) endowed with silver cores, which underwent incomplete degradation during the application, and the residues could potentially cause heavy metal enrichment and pollutions to the environment. Therefore, to address these challenges, we have developed an Ag-based coreless structure by substitution alkynyl Ag to chitosan (Ag-CS). In this structure, Ag was substituted to chitosan (CS) through a reversible chemical bond to form a coreless structure that was environmentally friendly and antimicrobial efficient. Transmission Electronic Microscopy, Energy-Dispersive X-ray Spectroscopy, and Inductively Coupled Plasma and were carried out to characterize the Ag-CS; Inhibition zone, growth curve measurement, and minimum inhibition concentration determination were performed to evaluate the antimicrobial efficacy; Cell viability test was carried out to assess the toxicity. The Ag-CS was proved to offer potent antimicrobial efficacy over either AgOAc or AgNO3 with the MIC of 6.4, 13.4, and 12.8 µg/mL silver equivalents, respectively. Ag-CS also provided a prolonged Ag release with a superior release rate of 90% in 5 days. Overall, the study indicated Ag-CS as a novel antimicrobial coating material that is antimicrobial efficient and environmentally friendly.

Development and evaluation of alkynyl silver substituted chitosan as an antimicrobial coating material

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.