Rotundial is a compound isolated from <i>Vitex rotundifolia</i>, a plant native to the seashore throughout the Pacific, which has been reported to have mosquito repellent properties. Here we first describe a modified high-throughput bioassay system used to measure the toxicity, contact irritancy and spatial repellency of rotundial on adult mosquitoes. In this bioassay system, Rotundial’s effectiveness was compared to identical concentrations of the most common currently used topical repellents, deet and picaridin.<br/>Second, we discuss a modified version of this setup that can evaluate painted surfaces for their spatial repellency properties. We then utilize this setup to evaluate both aluminum foil and painted aluminum foil to serve as a control for the experiments. Following this, we evaluate the spatial repellency of painted aluminum foil, with the paint embedded with different concentrations of Rotundial. We compare these results to the spatial repellency of the pure compound. A diffusion-based model is constructed to predict the long-term spatial repellency of the paint, based on the paint's thickness, loading of Rotundial, and local temperature.

Towards anti-mosquito paint via rotundial-based paint

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.