Addressing an unmet need for the treatment of wounds, we have developed bandages with antimicrobial, anti-inflammatory, and analgesic properties. We have fabricated electrospun polycaprolactone (PCL) scaffolds with the incorporation of Ag+IBU, a novel therapeutic, capable of aiding in the wound healing process, while delivering the drug locally at a controlled rate to impede bacterial infections. Scanning electron microscopy images reveal that our drug loaded scaffolds have a smooth fiber morphology and fiber diameter that is ~1 mm. Scaffolds loaded with either 5% or 10% Ag+IBU (w/w), were able to release 40% of the drug within the first 24 hours. Microbiological assays revealed that Ag+IBU-loaded scaffolds are bactericidal against bacteria in both planktonic and biofilm growth mode. While Ag+IBU-loaded scaffolds are toxic to human dermal fibroblasts with high drug loading, pre-treatment of cells with N-acetyl cysteine (NAC), abrogates this toxicity significantly increasing cell viability. Compared with the commercially available bandages with antimicrobial properties currently used for wounds, our antimicrobial, anti-inflammatory, and analgesic scaffolds offer a more comprehensive treatment option.

Electrospun antimicrobial, anti-inflammatory and analgesic bandages for comprehensive wound treatment

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.