According to WHO, the prevalence of obesity has tripled since 1975 and ~ 13% of the world’s population is obese. Obesity is the biggest risk factors for noncommunicable disease such as cardiovascular disease, type 2 diabetes, cancer and inflammatory disorders. Nutraceuticals such as xanthohumol (XN) have shown potential to inhibit adipogenesis, however, their bioavailability has remained controversial. Hence there is a need to develop targeted therapy, which will increase the concentration of xanthohumol in the adipose tissue. Currently, nanoparticles are used for drug delivery where conventional therapies have proven to be less effective. Among various types of nanoparticles, ultrasmall superpraramagnetic nanoparticles (USPIO) have found considerable attention in drug delivery as they are easy to synthesize, inert, and are biocompatible. Additionally, the use of magnetic nanoparticles as a drug delivering agent system under the influence of external magnetic field has received much attention. Thus our goal is to develop a XN loaded magnetic nanoparticles which when given via IV can be targeted to adipose tissues under the influence of external magnet. However, to use them for drug delivery, the USPIO need to be surface functionalized by ligands such as 3-aminotripropyl ethoxysilane. The use of 3-aminotripropyl ethoxysilane provides an amine functional group on the surface of USPIO. Once amine functionalized, the USPIO-NH2 will be conjugated to XN via dicarboxylic PEG linker (HOOC-PEG-COOH) to yield USPIO-PEG-XN. These XN loaded magnetic nanoparticles can be targeted to the adipose tissue under the influence of magnet. USPIO were synthesized by reacting Fe(II) and Fe (III) chloride salts in presence of NaOH. USPIO thus obtained were amine functionalized using 3-aminotripropyl ethoxysilane. TEM analysis revealed the presence of 20-25 nm particles for both USPIO and USPIO-amine. The presence of amine functional groups on the surface of nanoparticles was confirmed via FTIR and quantified using ninhydrin Assay. The ninhydrin assay revealed the presence of 4.5mM of amine groups per mg of the USPIO. Once synthesized the USPIO-PEG-XN will be evaluated for their specificity and toxicity both in vivo and in vitro.

Use of ultra-small superparamagnetic iron oxide nanoparticles (USPIO) to deliver xanthohumol to adipocytes

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.