Triple negative breast cancer (TNBC) is associated with aggressive tumor growth, metastasis and poor patient outcome (with ~10-20% of all breast cancers being identified as TNBCs). Prognosis has not improved for TNBC patients despite numerous advances in tumor diagnosis, surgical procedures, and radio/chemotherapy over the past few decades.  Hence there is a critical need for the development of novel and easily accessible therapeutics that show selective toxicity toward cancer cells (particularly drug resistant cancers).  Salinomycin is an antibiotic produced by Streptomyces albus that is used as an anti-coccidiostat in animal feed.  Salinomycin was recently found to exhibit anti-cancer stem cell activity against breast cancers.  One of the critical processes responsible for the cancer stem cell survival is the WNT/b-catenin pathway.  WNT-induced phosphorylation of the co-receptor LRP6 has been demonstrated to be responsible for the initiation of WNT/b-catenin signaling.  Salinomycin inhibits cell growth in several WNT dependent cancer cells via inhibition of phosphorylation of LRP6.  We recently took up a project involving the development of salinomycin analogs as potential anti-cancer  agents. Based on our investigation, we identified a salinomycin-thiadiazole conjugate as a lead compound.  Our synthetic and biological evaluation results will be presented.

Synthesis and biological evaluation of salinomycin analogs as potential anti-cancer agents

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.