Hospital-acquired infections (HAI) cause mortality and morbidity in hospitals. Although frequent cleaning with disinfectants can effectively prevent the contact transmission of microorganisms, surface corrosion, microbial tolerance and potential harmful residues resulting from ordinary chemical disinfectants are main concern. Pulsed blue LED lights are recently reported with obvious bactericidal activity. This study works on the bactericidal activities and mechanism of two types of pulsed blue light-470nm and 405nm. Results show that pulsed 470nm and 405nm blue LED lights not only save energy but also effectively reduce the gram positive and negative bacteria, and also have excellent performance on MDROs. By measuring the sub-lethal rate, DNA and Protein leakage from the bacteria, it reveals that 405nm light can deconstruction of the bacteria membrane. Genotoxicity test explain the bactericidal mechanism of 470nm light which is destroy the structure of bacterial DNA.

Bactericidal activity and mechanism of pulsed blue LED light

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.