The isotope Zr-89 is currently gaining greater interest for immuno-PET studies. This strongly Lewis-acidic metal ion has considerable affinity for bone, and decomplexation of Zr(IV) in vivo is a challenge. The addition of a fourth chelating group to desferrioxamine B (DFO) is a useful strategy to obtain biocompatible chelators with high Zr affinity. We will describe new homologated DFO derivatives which also provide a functional group for bioconjugation (example, Figure). The Zr(IV) binding properties and aqueous speciation chemistry of these bifunctional DFO homologs will be detailed.

High-affinity, bifunctional Zr(IV) ligands for immuno-PET imaging

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.