We have used the 12 principles of green chemistry to redesign the syntheses of two classes of pharmaceutical compounds: 3,5-diarylisoxazoles and phenylmaileimides.  Isoxazoles are a group of pharmaceuticals that are used as anti-convulsant, anti-epileptic and anti-inflammatory drugs. The conventional process used to make these molecules uses a number of hazardous chemicals and produces large amounts of waste. We have developed a more environmentally-friendly 4-step synthesis that yields multiple isoxazoles, uses less hazardous reagents, reduces waste, is more energy efficient, and is cost effective.  Maleimides are essential building blocks for a number of pharmaceuticals and herbicides.  We have developed a three-step synthesis for a variety of phenylmaleimide derivatives that has high atom economy, is energy efficiency, reduces waste and use of hazardous reagents and solvents, and is extremely cost effective.

Creating more efficient, less hazardous syntheses of pharmaceutical using the 12 principles of green chemistry

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.