In India 70 million are diabetic and are at risk of diabetic retinopathy, which can cause blindness if left untreated. Increased levels of methylglyoxal (MGO), a dicarbonyl compound derived from glucose is linked to clinical microvascular complications  causing nephropathy,retinopathy, and neuropathy. Our laboratory has studied mechanistic details of inhibition of advanced glycation end products (AGEs) using natural bioactive compounds from plants (ACS 2012,2014-2018).  MGO derived (AGEs) are responsible in causing macro-and micro-vascular complications in diabetes Type-2 patients. We are investigating target bioactive molecules found in Okra Seed Extract, bitter melon Peel for scavenging reactive reactive oxygen species in diabetes Type-2 and cardiovasular disease patients patients which we believe could be potentially useful in fighting diabetic blindness. Molecular characterization  of antioxidant  bioactives (Lutein, chlorogenic acid from bitter melon and flavonoids from okra seed extract and their trapping efficiency of MGO, a potent neurotoxin  was achieved. A critical role of Artificial Intelligence A.I.), a screening tool at an early stage for diabetic retinopathy identifying tiny lesions, hemorrages, discoloration resulting in blindnes will be described.  Also a description of biological significance of metabolic inhibitors (metformin, phenformin and a monoguanide 2-aminoguanidine) and their comparison with boiactives in inhibiting (AGEs) as well as their receptor will be discussed.

Dabetes as an environmental risk factor: Critical role of artificial intelligence (A.I.) as a screening tool in diabetic retinopathy

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.