One of the most recurrent issues encountered in the world of active pharmaceutical ingredients (APIs) is their low bioavailability, which is in part due to their poor dissolution in aqueous media. Researchers are actively pursuing a solution to this issue. Multiple studies have shown that the conversion of the solid state pharmaceuticals into liquid state or ionic liquids (ILs, ionic salts in liquid state comprised of a 1:1 cation to anion molar ratio) is one of the most promising routes to address these issues. An increase in the drugs solubility can be also achieved when three or more pharmaceuticals are combined in different molar ratios into a more complex IL, namely a double salt ionic liquid (DSIL). Albuterol is one of the most commonly used drugs in asthma treatment. Due to the aliphatic and aromatic regions present in its structure, the aqueous solubility of this drug is low, and its bioavailability hence is diminished. However, albuterol contains a basic amine site making it an ideal candidate for its conversion into a cationic form which can then be paired with organic anions to form new liquid state asthma medication. Our previous research showed that albuterol cation, a non-steroidal anti-inflammatory drug anion, and docusate anion can be successfully combined in different molar ratios to form the corresponding DSILs. Here, our research efforts are directed towards the aqueous solubility of the novel liquid state albuterol derivatives. Solubility studies were performed in phosphate buffered saline (PBS, an aqueous medium that mimics the ionic concentration, osmolality, and pH of blood) by following the reported procedures and the amount of the desired compound in the aqueous solution was quantified <i>via </i>UV-Vis spectroscopy.<br/>

Aqueous solubility of new albuterol drugs in liquid form

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.