A simple and convenient reaction protocol for the clean and high-yielding synthesis of various aromatic amines derived from reactions of phenols with ammonia under transition metal-free reaction conditions is described here. PEG-400 (Polyethylene Glycol-400) is employed as green reaction solvent. Pyridine was found to be the ideal catalyst and base for this transformation. The conversion rates and yields observed are excellent and in the majority of the reactions significantly higher yields were obtained than in their catalyzed versions. The reactions were performed with substituted benzyl alcohol and phenols. Phenols which are supposed to be harder to convert under metal free conditions, gave high yielding products under these newly developed reaction conditions. After optimization, the best reaction condition was found to be use of catalytic amount of Pyridine (0.1 equiv) and ammonia (1.2 equiv) for amination.

Green approach: Metal free amination of aromatic alcohols

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.