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Polysuccinimide is a biodegradable and tissue-friendly polymer made from the renewable monomer L-aspartic acid. However, under physiological conditions (pH = 7.4) it hydrolyzes to form water-soluble poly(aspartic acid). In order to utilize this polymer to produce drug-eluting fiber mats or tissue scaffolds via electrospinning, it needs to be crosslinked. This paper will discuss the functionalization of this polymer with allyl groups (Figure 1), electrospinning it into fiber mats and crosslinking it via non-equilibrium low pressure air plasma treatment. The polymers and mats were characterized before and after plasma treatment using NMR, FTIR, XPS and SEM. After plasma treatment the fiber mat became insoluble in its original solvents (DMF and DMSO). After hydrolysis of the amide bonds into aspartic acid fiber morphology changed as shown in Figure 2. This electrospun crosslinked fiber mat shows great promise for biomedical applications.
amino acids, acidic
amino acids, dicarboxylic
amino acids, peptides, and proteins
biomedical and dental materials
chemical actions and uses
excitatory amino acids
fluids and secretions
hemic and immune systems
metabolic networks and pathways
neoplasms by histologic type
neoplasms, bone tissue
neoplasms, connective and soft tissue
neoplasms, connective tissue
plant physiological phenomena
specialty uses of chemicals
technology, industry, and agriculture