The subjects of this talk are multifunctional mesoporous silica nanoparticles controlled by supramolecular nanomachines and caps for imaging and drug delivery in cells and <i>in vivo</i>.  The nanoparticles are designed to 1) trap therapeutic molecules inside of the nanocarriers, 2) carry therapeutics to the site of the disease with no leakage, 3) release a high local concentration of drugs, 4) release only on command – either autonomous or external, and 5) kill the cancer or infectious organism. The most important functionality is the ability to trap molecules in the pores and release them in response to desired specific stimuli.  Two types of external stimuli will be discussed: light and oscillating magnetic fields.  Activation by internal biological stimuli such as pH changes, redox potential changes, antibodies and enzymes will also be presented. Molecular machines based on molecules that undergo large amplitude motion when attached to mesoporous silica - impellers, snap-tops and valves – will be described. Derivatized azobenzene molecules, attached to the interior pore walls function as impellers that can move other molecules through the pores.  Nanoparticles containing anticancer drugs in the mesopores are taken up by cancer cells, and optical stimulation of the impellers drives out the toxic molecules and kills the cells. Snap-tops with cleavable stoppers release cargo molecules when the stopper is removed from the pore entrance. Nanovalves consisting of rotaxanes and pseudorotaxanes placed at pore entrances can trap and release molecules from the pores in response to stimuli. Both reusable and completely reversible nanovalves will be described. Activation of these nanodevices by the five types of stimuli in solution, in living cells, and in animal models will be discussed.  Applications to treatments of cancers (including pancreatic and breast) and of intracellular infectious diseases (including tuberculosis and tularemia) will be presented. <br/>

Stimuli-responsive nanoparticles controlled by supramolecular machines and caps for biomedical imaging and drug delivery

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.