Natural (+)-usnic acid is isolated from the species of Usnea lichen and demonstrates antibacterial, antiviral, antifungal and antibiofilm activity, including inhibition of the methicillin-resistant Staphylococcus aureus (MRSA) pathogen. In this pilot project, a small library of six phenyl amino (+)-usnic acid derivatives was synthesized, purified, and characterized using IR and 1H & 13C NMR spectroscopy. The antimicrobial impact of compounds against E. coli, S. aureus Newman and MRSA USA300 was also studied using the disk diffusion assay. This work demonstrated that synthetic compounds demonstrated bactericidal effects against MRSA and other related Staph pathogens, and laid an important foundation for further research.

Synthesis, characterization, and evaluation of synthetic phenyl amino (+)-usnic acid derivatives in anti-microbial disk diffusion assays

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.